Salve a tutti.
Nel mezzo del cammin di questo blog mi ritrovai per una selva oscura che la diritta via era smarrita…. No! non mi sono dato alla letteratura, anche se devo dire che Dante mi piace molto. Con il celebre inizio della divina commedia, voglio dire che è da molto tempo che con pubblico qualcosa di pseudo scientifico. Questo a causa di NOIE e FASTIDI vari. Ora cercherò di rimettere in carreggiata questa situazione.
Qualche tempo fa mi è capitato di discutere con un’amica, mentre ripassavamo farmacologia, del ruolo che
Ora voglio spiegare anche a voi come funziona un gas nervino, tanto più che, alcuni farmaci ANTITUMORALI, e un ANTIGLAUCOMA hanno delle analogie molto spiccate con le molecole che erano usate durante una battaglia in quello che è definito attacco chimico. Dal 25 aprile del 1915 quando a Ypres in Francia per la prima volta l’esercito tedesco impiego Cl2 come gas asfissiante, vi è stata una costante corsa allo studio di nuovi e più micidiali composti in grado di essere impiegati sul campo di battaglia. Dalla fine della seconda guerra mondiale si sono sviluppati i cosiddetti GAS NERVINI, vale a dire dei composti che vanno ad interagire specificatamente con alcuni elementi del sistema nervoso autonomo di un essere umano. In verità questi composti erano stati studiati inizialmente come pesticidi, ma per sfortuna, ed io aggiungerei, come sempre! la “bestia” uomo ha trovato il modo di usarli contro i propri simili. Queste molecole, di cui fa parte il gas Sarin (sotto riportato), tristemente famoso per il suo impiego per scopi terroristici, sono in grado di bloccare IRREVERSIBILMENTE (avviene una reazione chimica tra il fosforo del gas e il sito catalitico dell’enzima, senza possibilità di poterlo riattivare in tempi compatibili con la vita) un enzima (Acetilcolinesterasi) deputato all’inattivazione del neurotrasmettitore Acetilcolina. Questo messaggero chimico a livello delle terminazioni nervose autonomiche media un’infinità d’azioni, di cui una delle più importanti è l’induzione di BRADICARDIA (rallentamento del battito) a livello cardiaco. In condizioni normali appena arriva l’acetilcolina si ha l’effetto e subito dopo è inattivata da Acetilcolinesterasi, dopo avvelenamento da sarin o analoghi rimane attiva e continua la stimolazione, inducendo un rallentamento tale da fermare il cuore. Fortunatamente esistono degli antidoti che se somministrati in tempo possono evitare le conseguenze letali. Per prima cosa viene fatta un’iniezione intracardiaca di ATROPINA (antagonista competitivo dei recettori muscarinici per l’acetilcolina) per far cessare la stimolazione del neurotrasmettitore, poi è somministrato il 2-PAM che è in grado, sempre grazie ad una reazione chimica, di riattivare in tempi brevi l’enzima.
Il Pensiero etico mio è che si dovrebbe porre al BANDO seriamente questo tipo di armi purtroppo le superpotenze e anche i paesi in via di sviluppo mascherano con la scusa della ricerca scientifica la produzione di molte tonnellate l’anno di queste molecole, come deterrente
19 commenti:
Suuuper Articolone, molto molto interessante!!!
complimenti Giorgio l'argomento non era facile da spiegare! Inoltre non avendo trattato a lezione l'argomento del gas Nervino, ti ringrazio particolarmente di avermi integrato la lezione sugli inibitori irreversibili di Acetilcolinesterasi (come alcuni pesticidi come dici).
P.S. ho avuto l'onore di essere stato il 1500esimo visitatore del tuo blog!! Per cui: GRAAANDE GIORGIO!!!
molto interessante..e terribile!
cmq grazie di avermi edotta sull'argomento!
complimenti per i visitatori!salutti
Erica
grazie ragazzi... sono enormenemnte onorato di avere la vostra amicizia!
lo so che èterribile, ma come dicevano grandi generali del passato LA GUERRA è UNA BRUTTA BESTIA!
Paolo... non c'èdi che sono altresì enormenente onorato di avere un contro relatote tecnico come te! grande per il 1500!!
dating service new york [url=http://loveepicentre.com/]whoisjohngalt femaledating[/url] amaeuteur dating http://loveepicentre.com/ christian singles
post tramatic stress disorder [url=http://usadrugstoretoday.com/categories/anti-fungus.htm]anti fungus[/url] bilateral breast discharge pain itching http://usadrugstoretoday.com/products/femara.htm big breast asian woman http://usadrugstoretoday.com/products/evista.htm
bowling green drug and alcohol treatment program [url=http://usadrugstoretoday.com/products/crestor.htm]crestor[/url] new years weight loss seniors club [url=http://usadrugstoretoday.com/products/metformin.htm]gay muscle up[/url]
stress free guitar bridge [url=http://usadrugstoretoday.com/products/lariam.htm]lariam[/url] pale penis http://usadrugstoretoday.com/categories/party-pills.htm calcium fluoride skin http://usadrugstoretoday.com/products/relafen.htm
restaurant health scores [url=http://usadrugstoretoday.com/products/zanaflex.htm]zanaflex[/url] walk in medical clinics philadelphia pa [url=http://usadrugstoretoday.com/products/detrol.htm]when to get sunshine for vitamin d[/url]
lowering pressure in body ie blood and eye for headache relief [url=http://usadrugstoretoday.com/products/indocin.htm]indocin[/url] what does smoking pot do to your body http://usadrugstoretoday.com/products/crestor.htm auto immune disease in eyes of dogs http://usadrugstoretoday.com/products/ed-discount-pack-1.htm
costs a drug company for the active [url=http://usadrugstoretoday.com/products/alpha-lipoic-acid.htm]alpha lipoic acid[/url] king richard the lion heart [url=http://usadrugstoretoday.com/products/cialis.htm]dental insurance cooperativrs in new york[/url]
http://online-health.in/beconase/side-effects-of-beconase-aq
[url=http://online-health.in/asthma/asthma-child-school]drug free door deceratinos[/url] drugs without aspirin [url=http://online-health.in/anastrozole/anastrozole-powder]anastrozole powder[/url]
greenfield drug http://online-health.in/atacand/atacand-and-pregnency
[url=http://online-health.in/aristocort/aristocort-4-mg-where-to-buy]sulfa related drugs[/url] superglue as a drug abuse [url=http://online-health.in/betamethasone/clotrimazole-and-betamethasone]clotrimazole and betamethasone[/url]
erectile dysfunction and size http://online-health.in/atorvastatin
[url=http://online-health.in/azithromycin/azithromycin-macs]the master cleanse health reviews[/url] pulsatle drug delivery [url=http://online-health.in/azithromycin/penicillin-allergy-azithromycin]penicillin allergy azithromycin[/url] does a and p does drug screening [url=http://online-health.in/atrovent/atrovent-inhaler]atrovent inhaler[/url]
mercedes brand image http://autoexpress.in/pontiac/cochran/pontiac mercedes benz 140 picture
[url=http://autoexpress.in/radiator/svx/radiator]first auto acceptance des moines iowa[/url] automobile rankings [url=http://autoexpress.in/maserati/maserati/08]maserati 08[/url]
national automobile parts association http://autoexpress.in/rover/land/rover/service
[url=http://autoexpress.in/peugeot/peugeot/service/kent]jackson automobile[/url] insured value for an automobile [url=http://autoexpress.in/radiator/plastic/radiator/repair]plastic radiator repair[/url]
goodyear automobile http://autoexpress.in/scion/scion/tc/reviews
[url=http://autoexpress.in/scooter/jon/andreti/scooter]mercedes benz email address germany[/url] remington 550a auto [url=http://autoexpress.in/panoz/panoz/gt/ra/sale]panoz gt ra sale[/url]
travel certificates http://greatadventures.in/plane-tickets/plane-tickets-under-100-dollars wardrobe by samatha brown of travel channel
[url=http://greatadventures.in/flight/international-flight-consolidator]ups travel to caribean[/url] travel incentive in italian beauty farm [url=http://greatadventures.in/airlines/allegence-airlines]allegence airlines[/url]
travel trac i force inertial trainer reviews http://greatadventures.in/adventure/disney-californian-adventure
[url=http://greatadventures.in/tourism/tourism-industry-sector-council]travel photography workshops[/url] travel dvds england [url=http://greatadventures.in/lufthansa/american-airways-history]american airways history[/url]
swedish rail travel http://greatadventures.in/lufthansa/flight-british-airways-uk travel dominican republic [url=http://greatadventures.in/inn/strattford-inn-fenton-mo]strattford inn fenton mo[/url]
which is the best fashion magazine http://topcitystyle.com/gucci-men-brand12.html famous engagement ring designer [url=http://topcitystyle.com/just-cavalli-wellness-logo-dress-item2504.html]latex fashion[/url] journeys bc shoes
http://topcitystyle.com/richmond-outwear-brand18.html designer dress irish wedding [url=http://topcitystyle.com/?action=products&product_id=2332]designer purse knockoff[/url]
mr softee 8 inch dildo http://theporncollection.in/lubricant/stamping-lubricant
[url=http://theporncollection.in/lesbian-xxx/shanghai-lesbian]bleach hentai english[/url] free girls riding suction cup dildo vids [url=http://theporncollection.in/lesbian-xxx/lesbian-spanking-galleries]lesbian spanking galleries[/url]
eros lubricant http://theporncollection.in/gay-xxx/gay-male-porn-and-free
[url=http://theporncollection.in/mature-woman/mature-babaes]adult three wheel bicycle[/url] cut off anal skintags [url=http://theporncollection.in/gay-boy/free-local-gay-chat]free local gay chat[/url]
adult bronchiolitis http://theporncollection.in/porn-dvd/free-xenosaga-sex-porn-anime
[url=http://theporncollection.in/gay-xxx/barely-legal-gay-sex-pics-galleries]first time anal screaming[/url] fat black men porn stars [url=http://theporncollection.in/hentai-porn/hentai-kiddy-grade]hentai kiddy grade[/url]
porn star xxx http://theporncollection.in/gay-movie/oslo-gay-sex-beats
[url=http://theporncollection.in/best-porn/stryker-porn]deflowered teen virgin[/url] pictures of ruptured canine anal gland [url=http://theporncollection.in/porn-girl/pre-teen-preteen-young-porn-nymphette]pre teen preteen young porn nymphette[/url]
porn eskamo http://xwe.in/orgy/asian-sex-orgy
[url=http://xwe.in/hcg-oral/leaving-oral-roberts-university-students]teen girl porn xxx sex[/url] free virgin teen movies [url=http://xwe.in/erotic-video/erotic-deer-art]erotic deer art[/url]
carbon career and technical institute adult education center http://xwe.in/bondage/amputee-bondage
[url=http://xwe.in/ass-video/free-girls-fucked-in-ass]anal stimulation techniques[/url] household item dildo [url=http://xwe.in/blowjob/chloe-sevigny-blowjob-scene]chloe sevigny blowjob scene[/url]
adult theatre sluts http://xwe.in/adult-video/search-engines-for-adult-film-stars
[url=http://xwe.in/hcg-oral/oral-reading-fluency-assessment]melancholy of haruhi suzumiya hentai[/url] sex obsessed women porn [url=http://xwe.in/archive-adult]archive adult[/url]
free fat lesbian porn movies http://xwe.in/shemales/marge-attacks-shemales
[url=http://xwe.in/gay-anal/gay-nude-bodybuilders]cb 3000 dildo[/url] making money writing adult stories [url=http://xwe.in/thongs/ashley-and-mary-kate-in-thongs]ashley and mary kate in thongs[/url]
quality travel insurance http://xwa.in/tours travel agent ipoh
[url=http://xwa.in/maps/random-house-maps]travel pricing challenges[/url] travel map of new zealand [url=http://xwa.in/vacation-packages/florence-italy-vacation-package]florence italy vacation package[/url]
world multi trip travel insurance http://xwa.in/airline/southwest-airline-finances
[url=http://xwa.in/tourism/tourism-defnition]used travel trailer value[/url] travel trunk with drawers [url=http://xwa.in/maps/maps-nz]maps nz[/url]
senior citizen travel tour http://xwa.in/tours/hollywood-tours-rodeo-drive sri lanka travel agents [url=http://xwa.in/maps/maps-of-hawar-islands]maps of hawar islands[/url]
website for people learning to make clothes http://www.thefashionhouse.us/richmond-classic-denim-brand18.html crow indians clothes [url=http://www.thefashionhouse.us/grey-black-blue-outwear-color66.html]fashion forecasting[/url] spanish clothes in english
http://www.thefashionhouse.us/-shirts-with-colar-on-sale-category22.html designer tees [url=http://www.thefashionhouse.us/grey-sweaters-color1.html]lauren sussino[/url]
online gambling news http://wqm.in/betting_real-online-casino-betting-method union organizing casinos
[url=http://wqm.in/betting_betting-systems-for-three-card-poker]smarter mail gci casinos[/url] ttn lottery [url=http://wqm.in/poker-online_free-poker-room-money-no-deposits]free poker room money no deposits[/url]
gambling online play keno online http://wqm.in/betting_real-online-casino-betting-method
[url=http://wqm.in/jokers_jokers-updates]massachusetts state lottery results[/url] casinos no deposit [url=http://wqm.in/lottery_litigation-lottery]litigation lottery[/url]
abilene casinos http://wqm.in/blackjack_trump-blackjack-gamees oxford bingo bradford [url=http://wqm.in/casino-online_langley-casino]langley casino[/url]
ohio lottery pick 3 http://lwv.in/blackjack/blackjack-books how to play keno casino gambling games
[url=http://lwv.in/keno/michigan-keno-analyis]jackpot apparel[/url] las vegas tv show nude casino [url=http://lwv.in/casino-online/milacs-casino-events]milacs casino events[/url]
playing blackjack in vegas two dollar http://lwv.in/casino-playing-cards/plastic-bicycle-playing-cards
[url=http://lwv.in/keno/keno-internet-casino-game-gambling]map of casinos in tunica[/url] ufc betting ontario [url=http://lwv.in/keno/internet-keno-online-casinos]internet keno online casinos[/url]
software samsung blackjack 2 http://lwv.in/roulette/how-to-win-at-roulette horse racing betting pick [url=http://lwv.in/casino-playing-cards/golden-retriever-playing-cards]golden retriever playing cards[/url]
amature porn movie [url=http://moviestrawberry.com/films/film_the_prince_of_tides/]the prince of tides[/url] murderous intent movie http://moviestrawberry.com/countries/?page=6 sex in the city the movie
couple movie [url=http://moviestrawberry.com/films/film_the_great_white_hype/]the great white hype[/url] jarhead the movie http://moviestrawberry.com/hqmoviesbygenres/download-genre_thriller-movies/?page=11 dodge ball movie
movie splinter [url=http://moviestrawberry.com/films/film_frank/]frank[/url] hd movie downloads
silent movie actors [url=http://moviestrawberry.com/films/film_the_pursuit_of_happyness/]the pursuit of happyness[/url] catalina cruz blowjob movie http://moviestrawberry.com/films/film_six_thugs/ mac problem movie no reboot
spaceballs movie [url=http://moviestrawberry.com/films/film_swiss_family_robinson/]swiss family robinson[/url] cheeni kum movie http://moviestrawberry.com/films/film_metro/ movie clock tower jorge olguin
jasper 8 movie theater jasper indiana [url=http://moviestrawberry.com/films/film_fast_sofa/]fast sofa[/url] hostel 2006 movie http://moviestrawberry.com/films/film_constantine/ adult film movie database
red headed movie characters [url=http://moviestrawberry.com/films/film_small_time_crooks/]small time crooks[/url] mac os x automator workflows movie converter http://moviestrawberry.com/films/film_the_phantom_creeps/ date movie rss feed
movie search sydney [url=http://moviestrawberry.com/films/film_101_dalmatians/]101 dalmatians[/url] gay movie monster free 15 minutes
preteen sex movie [url=http://moviestrawberry.com/films/film_cliffhanger/]cliffhanger[/url] international movie data base http://moviestrawberry.com/films/film_shane/ nipple suck movie
why did i get married the movie [url=http://moviestrawberry.com/films/film_gorillas_in_the_mist_the_story_of_dian_fossey/]gorillas in the mist the story of dian fossey[/url] divx movie http://moviestrawberry.com/hqmoviesbyyear/year_1915_high-quality-movies/ erotic movie clips
Posta un commento